Shedding Light on Voltage-dependent Gating

Shedding Light on Voltage-dependent Gating

Voltage-dependent channels respond to changes in the transmembrane electric field by rearranging their voltage sensors, triggering increases in selective permeability. The channels reside in three types of conformationally distinct populations: closed states, open states, and a variety of inactivated states. These populations are closely interrelated and, while significant advances have been ma...

Coupling of Voltage-dependent Gating

I N T R O D U C T I O N Many K§ channels are inhibited by Ba ions. In the cases for which careful mechanistic studies have been carr ied out (Armstrong and Taylor , 1980; Eaton and Brodwick, 1980; Armst rong et al., 1982; Vergara and Latorre , 1983), the evidence argues that the Ba ion acts via a simple blocking scheme; it enters the conduct ion pathway o f the K § channel, where it binds tight...

Shedding new light on cathodoluminescence--a low voltage perspective.

Previously, imaging and analysis with cathodoluminescence (CL) detectors required using high accelerating voltages. Utilization of lower accelerating voltage for microanalysis has the advantages of reduced beam-specimen interaction volume, and thus better spatial resolution, as well as reduction in electron beam induced damage. This article will highlight recent developments in field emission g...

Shedding Light on Light*

There are four books describing early studies and views on light, optics and vision that are considered to be landmarks in this branch of science. The first of these is Euclid’s Optica, published about 300BC, in which he postulated that light travelled in straight lines; he described the laws of reflection and described them mathematically. The second is by Ptolemy. He is best known for his 15 ...

Voltage-dependent ion channels and their gating.